Is propofol neurotoxic to the developing brain?
نویسندگان
چکیده
منابع مشابه
Vulnerability of children and the developing brain to neurotoxic hazards.
For much of the history of toxicology, the sensitivity of the developing organism to chemical perturbation attracted limited attention. Several tragic episodes and new insights finally taught us that the course of early brain development incurs unique risks. Although the process is exquisitely controlled, its lability renders it highly susceptible to damage from environmental chemicals. Such di...
متن کاملbeta2-Microglobulin is potentially neurotoxic, but the blood brain barrier is likely to protect the brain from its toxicity.
BACKGROUND In dialysis-related amyloidosis, beta2-microglobulin accumulates as amyloid fibrils preferentially around bones and tendons provoking osteoarthritis. In addition to the pathologic role played by the amyloid fibrils, it can be speculated that a pathogenic role is also played by the high concentrations of soluble beta2-microglobulin because it is toxic for certain cell lines like HL60 ...
متن کاملβ2-microglobulin is potentially neurotoxic, but the blood brain barrier is likely to protect the brain from its toxicity
Background. In dialysis-related amyloidosis, β2microglobulin accumulates as amyloid fibrils preferentially around bones and tendons provoking osteoarthritis. In addition to the pathologic role played by the amyloid fibrils, it can be speculated that a pathogenic role is also played by the high concentrations of soluble β2-microglobulin because it is toxic for certain cell lines like HL60 and mi...
متن کاملDiminished experience-dependent neuroanatomical plasticity: evidence for an improved biomarker of subtle neurotoxic damage to the developing rat brain.
Millions of children are exposed to low levels of environmental neurotoxicants as their brains are developing. Conventional laboratory methods of neurotoxicology can detect maldevelopment of brain structure but are not designed to detect maldevelopment of the brain's capacity for plasticity that could impair learning throughout life. The environmental complexity (EC) paradigm has become classic...
متن کاملIs active psychosis neurotoxic?
Positive symptoms of psychosis disrupt mentation. Do they also engineer brain cell death and deterioration? This hypothesis is currently popular as an explanation of the duration of untreated psychosis effect in early schizophrenia. The clinical and neurobiological evidence for its validity is visited and found wanting. Synaptic plasticity, not neurotoxicity, appears to be the mediating process.
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ژورنال
عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie
سال: 2006
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03022872